Advertised as the “new super-powerful fat burner,” Novex Biotech’s Thermodyne is designed to support beach-ready bodies.

I looked into Thermodyne to see if it’s the amazing fat burner Novex Biotech describes in advertisements.

What’s in Thermodyne?

Thermodyne provides two blends of various ingredients intended to enhance lipid oxidation and facilitate lean body mass.

Fat Burning Blend (509 mg)

Citrus Sinensis l. Osbeck
Better known as sweet orange or navel orange, citrus sinensis l. osbeck inhibits fat accumulation in mice.[1]

However, there is a lack of research regarding citrus sinensis l. osbeck effect on fat accumulation in humans.

Citrus Paradisi
More commonly known as grapefruit, citrus paradisi is often touted as an effective ingredient for fat burn and weight loss. However, I wasn’t able to find any clinical evidence showing citrus paradisi facilitates lipid oxidation.[2]

Citrus Macracantha
Citrus macracantha is another name for citrus sinensis l. osbeck, the sweet orange.[3] I’m not sure why Novex Biotech chose to list the same ingredient twice, under different names.

Conjugated Linoleic Acid (CLA)
CLA is clinically proven to promote fat burn and facilitate greater lean body mass.[4]

A 2007 survey of clinical trials shows 3.2 grams of CLA produces modest body fat loss in humans.[5] Thermodyne’s CLA content is likely much smaller than this amount.

Energy Blend (493 mg)

Arabica Coffee Bean
Arabica coffee bean contains caffeine, a substance clinically proven to promote fat burn by enhancing thermogenesis, resulting in significant weight loss.[6]

Clinical research shows daily caffeine doses of 100 mg or more promotes fat burn.[7] Since the average caffeine content of one cup of coffee is 150 mg, Thermodyne likely contains enough Arabica coffee bean to promote weight loss.

Paullinia Sorbilis
Paullinia sorbilis, commonly known as guarana, is rich in caffeine. Likely due to its caffeine content, guarana has been clinically proven to promote fat burn and weight loss.[7]

While an effective guarana dose various with the individual, one clinical study found daily guarana doses of 300 mg facilitates fat burn in most subjects.[8] It’s unknown whether Thermodyne contains a similar amount.

Theobroma Cacao Seed
Better known as the cocoa bean, theobroma cacao seed decreased visceral fat tissue weight in rats in one study.[9] It also inhibits fatty tissue accumulation.[9]

As clinical evidence on cocoa bean is mainly animal-based, Its effect on human weight loss is unclear.

Sterculia Acuminata
Sterculia acuminate (kola nut) contains caffeine, a well-known stimulant that promotes thermogenesis.[10]

While effective dosage amount various with the individual, caffeine-induced thermogenesis tends to promote fat burn and weight loss. It’s unknown just how much caffeine sterulia acuminate contains.

Are These Ingredients Safe to Use?

The caffeine content in several Thermodyne ingredients is the biggest cause for concern. High caffeine doses cause side effects such as stomach pain, diarrhea, muscle twitching, and even seizure.[11]

Grapefruit is also a concern because studies show it interacts with several medications, causing serious side effects.[12] These medications include Artemether, Buspirone, Carbamazepine, and Carvedilol.

If you’re taking medications, consult your physician before using Thermodyne.

How to Use Thermodyne

Take 2 capsules in the morning and another 2 capsules with your main meal of the day.

Do not take more than 4 capsules in one 24-hour period.

The effects of Thermodyne can be optimized when added to diet and exercise.

Also, Thermodyne contains a lot of caffeine, so avoid taking it within 6 hours of sleep because it could interfere with your sleep.

Purchasing Thermodyne

Thermodyne can be purchased from various online vendors. A 120-capsule box can be purchased for $59.99 plus shipping and handling fees from and This makes Thermodyne expensive as most comparable fat burners sell for around $30.00.

Is Thermodyne a Worthwhile Fat Burner?

While Thermodyne contains some proven ingredients that promote fat burn, it also has some issues that stop me from recommending it.

First, many of its other ingredients are unproven and are part of a proprietary blend. This makes the formula’s effectiveness difficult to gauge.

Second, there are no user reviews supporting the product’s effectiveness.

Third, at $59.99 a box, Thermodyne is significantly more expensive than comparable fat burners.

Thermodyne may work, but I would pass it by and find a cheaper, more effective fat burner.


1 Comment Jump To Comment Form
  1. by seejake

    thank you! I found this stuff to be a good stimulant, but not much else.

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[1] Titta, L., et al. "Blood orange juice inhibits fat accumulation in mice." International Journal of Obesity, 34.3 (2009): 578-588.Available from:

[2] “The Grapefruit Diet.” Accessed 6.13.2013.Available from:

[3] “Sweet Orange: Other Names.” Accessed 6.13.2013. Available from:"

[4] Park, Yeonhwa, and Michael W. Pariza. "Mechanisms of body fat modulation by conjugated linoleic acid (CLA)." Food Research International, 40.3 (2007): 311-323. Available from:"

[5] Whigham, Leah D., et al. "Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans." The American Journal of Clinical Nutrition, 85.5 (2007): 1203-1211.Available from:

[6] Suzuki, Takeo, and George R. Waller. "Biodegradation of caffeine: formation of theophylline and theobromine from caffeine in mature Coffea arabica fruits." Journal of the Science of Food and Agriculture, 35.1 (1984): 66-70. Available from:

[7] Dulloo, A. G., et al. "Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers." The American Journal of Clinical Nutrition, 49.1 (1989): 44-50.Available from:

[8] Boozer, C. N., et al. "An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial." International Journal of Obesity, 25.3 (2001): 316-324. Available from:

[9] Matsui, Naoko, et al. "Ingested cocoa can prevent high-fat diet-induced obesity by regulating the expression of genes for fatty acid metabolism." Nutrition, 21.5 (2005): 594-601. Available from:

[10] “Cola Nut Overview Information.” Accessed 6.21.2013. Available from:

[11] “Caffeine Side Effects.” Accessed 6.13.2013. Available from:

[12] CBC News. “Grapefruit Juice Interaction With Drugs Can be Deadly.” Accessed 6.13.2013. Available from: